Questions about Sleep-eze®

The main active ingredient in Sleep-eze is diphenhydramine hydrochloride, an antihistamine that acts as a nighttime sleep aide to help relieve occasional sleeplessness.

The main ingredient, diphenhydramine hydrochloride, works by blocking a natural chemical in your body called histamine. Histamine affects your sleep-wake cycle and cognitive (thinking) function so too much can keep you awake. By blocking histamine, you feel drowsy and may fall asleep faster and stay asleep.

While there are no gluten or wheat-based ingredients in Sleep-eze products, we cannot guarantee our sleep medicine is manufactured in a facility that does not also process wheat-based or gluten-containing items.

Sleep-eze^® eze-free^TM liquid does not contain any dye or artificial colours.

All other Sleep-eze^® products—Sleep-eze^® eze-melts^®, Sleep-eze^® eze-liquid^TM, and Sleep-eze^® Extra Strength Minis, Extra Strength GelCaps, and Extra Strength Caplets do contain dye.

Most Sleep-eze^® products do not contain lactose. If you are lactose intolerant, you can use these lactose-free products: Sleep-eze^® eze-free^TM liquid, Extra Strength GelCaps, Sleep-eze^® eze-melts^® and Sleep-eze^® eze-liquid^TM.

Sleep-eze^® Extra Strength Minis, Extra Strength Caplets and Regular Strength Caplets contain lactose, so do not use if you are lactose intolerant.

• Sleep-eze^® Extra Strength Minis, Extra Strength Caplets and Regular Strength Caplets contain no sugar or artificial sweeteners.
• Sleep-eze^® eze-free^TM liquid contains sucralose and xylitol.
• Sleep-eze^® Extra Strength GelCaps contain sorbitol.
• Sleep-eze^® eze-melts^® contain sucralose.
• Sleep-eze^® eze-liquid^TM contains high fructose corn syrup and sodium saccharin.

Sleep-eze^® eze-free^TM liquid contains no alcohol, dye or sucrose. Our other liquid product—berry-flavored Sleep-eze^® eze-liquid^TM—contains ethyl alcohol.

While our products are not certified as vegan, Sleep-eze^® products contain no animal-based ingredients. However, we cannot guarantee these products are manufactured in a facility that does not process animal byproducts

The current Sleep-eze product line does not contain melatonin.

Sleep-eze is the #1 medicated sleep brand in Canada and, when used as directed in adults or children over 12, is a safe and effective way to relieve occasional nighttime sleeplessness. However, if you have any health conditions, are on other medications, are over age 65, or are pregnant or breastfeeding, you should talk to your doctor before using any medicated sleep aid or natural supplement.

Anyone over age 65 should use caution when taking Sleep-eze or any medicated or natural sleep aid, especially if they have any neurologic condition or confusion. Sleep aids can have the opposite effect in elderly adults and cause an increase in sleeplessness or confusion. A quick check with your doctor is smart to find the product best suited for your personal needs.

Children aged 12 and over can safely use Sleep-eze sleep aids when supervised by an adult; however, the product should be kept out of reach of all children to help prevent potential accidental overdose. If your child is taking other medications or has any health conditions, please check with their doctor before using any sleep aid.

While no serious side effects or long-term effects on the parent or baby have been shown, if you are pregnant or breastfeeding, you should talk to your doctor first before using any sleep aid, natural or medicated.

While it can be difficult to sleep when you’re sick or if you’re suffering from a chronic health condition, it’s important you discuss taking sleep aids with your doctor before using them. Show your doctor the ingredients in the types of products you wish to use so they can help you make the best decision for you.

Sleep-eze contains no nuts or nut-based ingredients; however, we cannot guarantee our sleep aids were manufactured in a nut-free facility.

One of the reasons Sleep-eze is rated as the #1 medicated sleep aid brand is because we give people a variety of options to suit a range of personal needs. If you have trouble swallowing pills, you can use one of our liquids—Sleep-eze^® eze-liquid^TM or alchol-free, dye-free Sleep-eze^® eze-free^TM liquid—or Sleep-eze^® eze-melts^® which dissolve on your tongue.

Great question! It’s true this ingredient is also used to reduce allergic reactions, but Sleep-eze is made specifically as a nighttime sleep aid so the dose and directions are typically different. If you are taking allergy meds and want to add a sleep aid, please talk to your doctor first and let them see the ingredients list for each medicine.

No. Sleep-eze sleep aids are not habit forming, but if have an addiction to any other substance, it’s safer to talk to doctor first to make sure this is the right choice for you. Also, Sleep-eze sleep medication is only meant to be used for occasional sleeplessness. If sleep problems last more than 2 weeks while taking Sleep-eze, stop taking the medicine and call your doctor for next steps.

Potential side effects tend to be mild and are similar to those of allergy meds, such as dry mouth, headache, daytime drowsiness, dizziness, nausea, as well as confusion or memory problems in older age groups. If you experience any side effects, stop using the medication and talk to your doctor.

Talk to your doctor if you take any other medications to be sure the mix of Sleep-eze and your other drugs won’t cause any breathing problems or other harmful effects.

Unless otherwise advised by your doctor, the lowest dose of Sleep-eze is 25 mg (regular strength) and the maximum dose is 50 mg (extra strength).

The minimum dose of Sleep-eze available is 25 mg or 15 mL (liquid). If you have any questions about what dose is best for you, please talk to your doctor.

The maximum dose that is safe for most adults is 50 mg or 30 mL (liquid). If you have any questions about what dose is best for you, please talk to your doctor.

Technically, it is safe to cut the tablets and caplets in half; however, we do not recommend cutting them. Our tablets and caplets do not have score lines on them which would make them easier to cut, so you could end up with an ineffective or less effective dose. Gelcaps are not meant to be cut at all.

Typically, Sleep-eze sleep aids start working pretty quickly. However, we do not give a time frame because even with medication, the time in which someone falls asleep can vary from person to person.

Sleep-eze is designed to help you fall asleep quickly, stay asleep through the night and wake up feeling refreshed, not groggy. Like most other medicines, results may vary in different people. It also helps if you adopt healthy sleep habits, such as limiting caffeine and alcohol, putting away all digital devices an hour or two before bed, and creating a sleep environment that helps you sleep better.

While Sleep-eze can help with occasional sleeplessness, the best way to solve long-term sleep problems is to consult with your doctor so you can address other factors that are causing or contributing to poor sleep. For example, you may want to avoid caffeine after 10 a.m. or create a routine that helps you relax before bedtime.

The timing varies from person to person. The effects of diphenhydramine hydrochloride (the main ingredient in Sleep-eze) work for about 4 to 8 hours whether you take the liquid, tablet or capsule form.

Sleep-eze^® eze-liquid™ has 54 calories in a 30 mL dose.

Store Sleep-eze^® eze-liquid^TM and Sleep-eze^® eze-free^TM at room temperature (20°C to 25°C or 68°F–77°F) away from sun or direct heat. There is no need to refrigerate.

It’s best to store Sleep-eze^® tablets, melts, caplets and gelcaps at or near room temperature and away from direct heat or sunlight to prevent melting.

All products typically start working after consuming, but this timing can be different from person to person.

If you take Sleep-eze sleep aids before bedtime with 8 hours until you wake up, you should wake up feeling refreshed. If you feel sleepy or drowsy in the morning, try a lower dose at night.

Do not take Sleep-eze if you wake up halfway through the night because you may not have enough hours left before you wake for the medicine to work properly and for the sleepiness to fade away.

Yes, you can use our online form to send us questions, email us at service@prestigebrands-custsvc.info or mail your questions or comments to:

Prestige Brands, Inc.
Corporate Communications
660 White Plains Road, Suite 250
Tarrytown, NY 10591

No. We do not conduct animal testing for any of our products and would not unless a specific regulation required us to do so and no other alternative existed. At present, there is no such regulation for medicated sleep aids like Sleep-eze^®.

You can buy Sleep-eze^® sleep aids at certain stores near you, as well as some online e-retailers. Please check our Where to Buy page for more information.

It’s important to keep in mind that sleep aids such as Sleep-eze^® products are meant to help with occasional nighttime sleeplessness, not long-term issues. Sleeplessness that persists for more than 2 weeks could be a sign of a more serious underlying health condition. If you aren’t sure whether you should take a sleep medication, talk to your doctor who can help you find the best solution for your needs.